Compositions and methods for angiogenesis-related molecules...

Details Compositions and methods for angiogenesis-related molecules... Compositions and methods for angiogenesis-related molecules...

C - Chemistry, Metallurgy

12

N

C12N 15/11 (2006.01)

Patent

CA 2576228

Short interfering RNA (siRNA) molecules which modulate the expression of an angiogenesis-related gene by RNA interference are described. Short hairpin RNA (shRNA) molecules comprising said siRNA molecules are also described. These molecules can target all, or specific, isoforms of the gene. The use of these molecules and of isoforms of the gene for the treatment and diagnosis of angiogenesis-related disorders is also described.

La présente invention décrit les molécules de petits fragments d~ARN interférant (siRNA) qui modulent l~expression d~un gène lié à l~angiogénèse par interférence de l~ARN. Elle décrit également les molécules d~ARN en petites épingles à cheveux (shRNA) comprenant lesdites molécules de siRNA. Ces molécules peuvent cibler tous les isoformes ou des isoformes spécifiques du gène. Il est également décrit l~utilisation de ces molécules et d~isoformes du gène pour le traitement et le diagnostic de troubles liés à l~angiogénèse.

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