Compositions and methods for antisense inhibition of protein...

Details Compositions and methods for antisense inhibition of protein... Compositions and methods for antisense inhibition of protein...

A - Human Necessities

61

K

A61K 48/00 (2006.01) A61K 31/70 (2006.01) C12N 15/11 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2256358

Compositions and methods are provided for inhibiting the translation of a capped target mRNA. Antisense oligomers of the invention are targeted to the 5' cap region of the target mRNA and include oligonucleosides, PNAs, or oligonucleotides modified at the 2' position of the sugar. Preferably, said oligomers inhibit protein translation directly via interference with ribosome assembly.

L'invention concerne des compositions et des procédés pour inhiber la traduction d'un ARNm cible à chapeau. Les oligomères antisens selon l'invention sont dirigés vers la région 5' de chapeau de l'ARNm cible et comportent des oligonucléotides, des PNA ou des oligonucléotides modifiés en position 2' du sucre. De préférence, lesdits oligomères inhibent la traduction des protéines directement par interférence avec un ensemble ribosomique.

Affiliated with

Also associated with

Rating

Compositions and methods for antisense inhibition of protein... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Compositions and methods for antisense inhibition of protein..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Compositions and methods for antisense inhibition of protein... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1515983