Compositions and methods for array-based genomic nucleic...

C - Chemistry – Metallurgy – 07 – H

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C07H 21/00 (2006.01) C07B 61/00 (2006.01) C07K 1/107 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01)

Patent

CA 2446050

The invention provides biological molecules modified by reaction with a compound having the formula (I): R1-X-R2, wherein R1 is a cyclic ether group or an amino group, R2 is an alkoxysilane group and X is a moiety chemically suitable for linking the cyclic ether group or the amino group to the alkoxysilane group. The invention also provides arrays, or "biochips", comprising these modified biological molecules. Also provided are methods for making and using these compositions.

L'invention concerne des molécules biologiques modifiées par une réaction avec un composé de formule R¿1?-X-R¿2?, dans laquelle R¿1? représente un groupe éther cyclique ou un groupe amino, R¿2? représente un groupe alcoxysilane et X représente une fraction chimiquement apte à lier le groupe éther cyclique ou le groupe amino au groupe alcoxysilane. L'invention concerne également des jeux ordonnés d'échantillons, ou "puces à ADN", contenant lesdites molécules biologiques modifiées. L'invention concerne encore des procédés de fabrication et d'utilisation de ces compositions.

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