G - Physics – 01 – N
Patent
G - Physics
01
N
G01N 33/50 (2006.01) C12N 15/72 (2006.01) C12Q 1/02 (2006.01) C12Q 1/04 (2006.01) G01N 33/542 (2006.01) G01N 33/58 (2006.01)
Patent
CA 2375542
The invention provides compositions and methods for monitoring subcellular compartments such as organelles by energy transfer techniques that do not require specific intermolecular affinity binding events between energy transfer donor and energy transfer acceptor molecules. Provided are methods for assaying cellular membrane potential, including mitochondrial membrane potential, by energy transfer methodologies including fluorescence resonance energy transfer (FRET). Diagnostic and drug screening assays are also provided.
L'invention concerne des compositions et des procédés de surveillance de compartiments infracellulaires, tels que les organites, au moyen de techniques de transfert d'énergie ne nécessitant pas d'événements spécifiques de liaison intermoléculaires par affinité entre des molécules donneuses de transfert d'énergie et des molécules receveuses de transfert d'énergie. L'invention concerne également des procédés d'analyse du potentiel de membranes cellulaires, dont le potentiel de membranes mitochondriales, par des techniques de transfert d'énergie comprenant le transfert d'énergie de résonance de fluorescence (FRET). L'invention concerne en outre des méthodes diagnostiques et des tests de criblage de médicaments.
Dykens James A.
Ghosh Soumitra S.
Velicelebi Gonul
Gowling Lafleur Henderson Llp
Mitokor
LandOfFree
Compositions and methods for assaying subcellular conditions... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Compositions and methods for assaying subcellular conditions..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Compositions and methods for assaying subcellular conditions... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1650576