A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 45/00 (2006.01) A61K 31/197 (2006.01) A61K 31/221 (2006.01) A61K 38/05 (2006.01) A61P 39/06 (2006.01)
Patent
CA 2633361
The present invention relates to a S-nitrosated mitochondria-targeted thiol-based antioxidant prodrug and uses therefore for the prevention or treatment of diseases or conditions associated with mitochondrial dysfunction resulting from changes in the mitochondrial redox environment. When activated, prodrug of the present invention can specifically provide a NO* donor and a thiol-based antioxidant to mitochondria thereby decreasing the degree of mitochondrial dysfunction.
La présente invention concerne un promédicament antioxydant à base de thiol S-nitrosé ciblant les mitochondries, et ses utilisations dans la prévention ou le traitement de maladies ou d'états pathologiques associés à un dysfonctionnement des mitochondries résultant de changements de l'environnement d'oxydo-réduction mitochondrial. Lorsqu'il est activé, le promédicament de la présente invention peut délivrer un donneur de NO<SUP>*</SUP> et un antioxydant à base de thiol, réduisant ainsi le degré de dysfonctionnement mitochondrial.
Anders Marion W.
Brookes Paul S.
Sheu Shey-Shing
Borden Ladner Gervais Llp
University Of Rochester
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