C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 7/01 (2006.01) A61K 31/166 (2006.01) A61K 35/76 (2006.01) A61P 35/00 (2006.01) C07C 235/84 (2006.01) C12Q 1/70 (2006.01)
Patent
CA 2697169
Disclosed are compositions and methods for augmenting activity of oncolytic viruses. Virus activity is augmented by sensitizing cancer or tumour cells through modulation of the Endoplasmic Reticulum (ER) stress response pathway, for instance by introducing into a tumour cell an agent effective to modulate ER stress response and sensitize the tumour cell. The tumour cells are then contacted with an oncolytic virus in an amount effective to reduce viability of the sensitized tumour cell. The oncolytic virus is thereby rendered more effective at lysing or killing the sensitized tumour or cancer cells.
Mahoney Douglas
Stojdl David
Children's Hospital Of Eastern Ontario Research Institute
Gowling Lafleur Henderson Llp
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