Compositions and methods for cancer diagnosis and therapy

Details Compositions and methods for cancer diagnosis and therapy Compositions and methods for cancer diagnosis and therapy

A - Human Necessities

61

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A61K 48/00 (2006.01) A61K 9/127 (2006.01) A61K 31/70 (2006.01) A61K 31/7088 (2006.01) A61K 35/12 (2006.01) A61P 35/00 (2006.01) C12N 15/12 (2006.01) C12N 15/63 (2006.01) C12N 15/85 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2504605

The miR15 and miR16 micro RNA genes are located at 13q14 within a 30 kb region of loss characteristic of cells from certain cancers, such as cells from chronic lymphocytic leukemia or prostate cancer. Chronic lymphocytic leukemia or prostate cancer can be diagnosed by detecting a reduction in miR15 or miR16 gene copy number, by determining miR15 or miR16 gene mutational status, or by detecting a reduction in the RNA transcribed from these genes. The miR15 or miR16 gene products can inhibit neoplastic or tumorigenic growth of cancers such as chronic lymphocytic leukemia or prostate cancer cells when administered to subjects suffering from these diseases. Fig. 3b shows a loss of heterozygosity analysis of microsatellite markers D13S272 and D13S273 in 18 chronic lymphocytic leukemia patients.

Les micro-gènes d'ARN miR15 et miR16 sont situés en 13q14 à l'intérieur d'une région de 30 kb de la caractéristique de perte de cellules provenant de certains cancers, notamment des cellules provenant de la leucémie lymphocytaire chronique ou du cancer de la prostate. En l'occurrence, pour diagnostiquer la leucémie lymphocytaire chronique ou le cancer de la prostate, on propose de détecter une réduction du nombre de copies du gène miR15 ou miR16, de déterminer le statut de mutation du gène miR15 ou miR16, ou de détecter une réduction affectant l'ARN transcrit à partir de ces gènes. Les produits géniques de miR15 ou miR16 sont capables d'inhiber la croissance néoplasique ou tumorigène de cancers tels que la leucémie lymphocytaire chronique ou le cancer de la prostate lorsqu'ils sont administrés à des sujets souffrant de ces maladies.

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