Compositions and methods for cancer gene discovery

Details Compositions and methods for cancer gene discovery Compositions and methods for cancer gene discovery

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01) A01K 67/027 (2006.01) A61K 39/395 (2006.01) A61P 35/00 (2006.01) C12N 15/00 (2006.01) C12Q 1/00 (2006.01) C40B 30/00 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2687787

The present invention features transgenic non-human mammalian animals being genetically modified to develop cancer. The invention also relates to methods for identifying genes or genetic elements that are potentially related to human cancers using an chromosomally unstable animal model. Information on such genetic alterations can be used to predict cancer therapeutic outcomes and to stratify patient populations to maximize therapeutic efficacy.

Cette invention concerne des animaux mammifères non humains transgéniques génétiquement modifiés pour développer un cancer. Cette invention concerne des procédés permettant d'identifier des gènes ou des éléments génétiques potentiellement associés aux cancers humains au moyen d'un modèle animal présentant une instabilité chromosomique. Des informations sur de telles altérations génétiques peuvent être utilisées pour prédire des résultats thérapeutiques sur cancer et pour stratifier des populations de patients afin de maximiser l'efficacité thérapeutique.

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