C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/10 (2006.01) A61P 37/00 (2006.01) C07K 14/00 (2006.01) C07K 14/47 (2006.01) C07K 19/00 (2006.01) C12N 9/64 (2006.01) C12P 21/06 (2006.01)
Patent
CA 2393333
This invention provides methods and compositions for caspase-induced apoptosis. Chimeric proteins are provided that target cells in which apoptosis is to be induced. The chimeric proteins of this invention activate endogenous caspase or provide caspase units that cause cell death. Methods are provided for the use of the chimeric proteins of this invention for in vivo and ex vivo therapies to treat pathological conditions.
La présente invention concerne des méthodes et des compositions destinées à l'apoptose induite par caspase, ainsi que des protéines chimères renfermant des cellules cibles dans lesquelles l'apoptose doit être induite. Ces protéines activent la caspase endogène ou produisent des groupes de caspase qui provoquent la mort cellulaire. Cette invention a également trait à l'utilisation des protéines chimères dans le cadre de thérapies in vivo et ex vivo en vue de traiter des conditions pathologiques.
Sim & Mcburney
University Of Louisville Research Foundation Incorporated
LandOfFree
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