Compositions and methods for cell transformation

Details Compositions and methods for cell transformation Compositions and methods for cell transformation

C - Chemistry, Metallurgy

12

N

C12N 15/87 (2006.01) A61K 31/575 (2006.01) A61K 47/28 (2006.01) A61K 48/00 (2006.01) C07J 9/00 (2006.01) C07J 17/00 (2006.01) C07J 31/00 (2006.01) C07J 41/00 (2006.01) C07J 43/00 (2006.01) C07J 51/00 (2006.01) C12N 15/11 (2006.01)

Patent

CA 2188320

The present invention relates to methods and compositions for the transformation of cells. In particular, compositions and methods are disclosed which include combinations of the nucleic acid of interest and polybyfroxylated or polyglycosylated steroid molecules. Most preferably, exogenous or endogenous nucleic acid is contacted with the cell in the presence of a bile acid (e.g., cholic acid) derivatized with an amine-containing side chain.

La présente invention concerne des procédés et compositions de transformation de cellules et plus particulièrement des compositions et procédés faisant intervenir l'acide nucléique concerné et des molécules de stéroïdes polyhydroxylatés ou polyglycosylatés. Selon une réalisation préférée, un acide nucléique exogène ou endogène est mis en contact avec la cellule en présence d'un dérivé d'un acide biliaire (par exemple l'acide cholique) obtenu grâce à une chaîne latérale contenant une amine.

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