Compositions and methods for clones containing dna sequences...

C - Chemistry – Metallurgy – 12 – N

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530/13, 167/37,

C12N 15/09 (2006.01) A61K 39/385 (2006.01) A61K 47/48 (2006.01) C07H 21/04 (2006.01) C07K 14/705 (2006.01) C12Q 1/68 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1341013

Genomic and cDNA clones of human genes which are selectively amplified or overexpressed in multidrug-resistant human tumor cells were isolated. Such clones may be used as probes in diagnostic tests to detect chemotherapy-resistant tumor cells and to predict tumor response to chemotherapy. The complete nucleotide sequence of the coding region of the human mdr1 gene and the complete corresponding amino acid sequence are disclosed.

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