C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
530/13, 167/37,
C12N 15/09 (2006.01) A61K 39/385 (2006.01) A61K 47/48 (2006.01) C07H 21/04 (2006.01) C07K 14/705 (2006.01) C12Q 1/68 (2006.01) A61K 38/00 (2006.01)
Patent
CA 1341013
Genomic and cDNA clones of human genes which are selectively amplified or overexpressed in multidrug-resistant human tumor cells were isolated. Such clones may be used as probes in diagnostic tests to detect chemotherapy-resistant tumor cells and to predict tumor response to chemotherapy. The complete nucleotide sequence of the coding region of the human mdr1 gene and the complete corresponding amino acid sequence are disclosed.
533183
Gottesman Michael M.
Pastan Ira H.
Roninson Igor B.
Board Of Trustees Of University Of Illinois
Ridout & Maybee Llp
LandOfFree
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