Compositions and methods for combined therapy of disease

Details Compositions and methods for combined therapy of disease Compositions and methods for combined therapy of disease

C - Chemistry, Metallurgy

12

N

C12N 15/79 (2006.01) A61K 31/7088 (2006.01) A61K 31/713 (2006.01) A61K 48/00 (2006.01) A61P 35/00 (2006.01) C12N 15/12 (2006.01) C12N 15/18 (2006.01)

Patent

CA 2551100

A desired physiological state can be induced by altering the amount of gene products in target cells of a subject. The target cells are treated with at least one compound designed to reduce expression of at least one first gene by RNAi, and with at least one compound designed to increase expression from at least one second gene. The reduced expression of the first gene and the increased expression from the second gene in the target cells induces the desired physiological state in the subject. By altering target cell gene expression in this way, conditions such as angiogenesis or tumor growth and metastasis can be inhibited.

La présente invention a trait à un procédé permettant d'induire une condition physiologique souhaitée par la modification de produits génétiques dans des cellules cibles d'un sujet. Les cellules cibles sont traitées avec au moins un composé destiné à réduire l'expression d'au moins un premier gène par l'ARNi, et avec au moins un composé destiné à accroître l'expression à partir d'au moins un deuxième gène. L'expression réduite du premier gène et l'expression accrue à partir du deuxième gène dans les cellules cibles induit la condition physiologique souhaitée chez le sujet. Grâce à la modification de l'expression génétique des cellules cibles de cette manière, des conditions telles que l'angiogenèse ou la croissance et métastase tumorale peuvent être inhibées.

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