C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 39/00 (2006.01) A61K 39/002 (2006.01) A61K 39/116 (2006.01) A61K 39/295 (2006.01) A61K 39/385 (2006.01) A61K 39/395 (2006.01) C07K 14/435 (2006.01) C07K 16/18 (2006.01) C07K 19/00 (2006.01) C12N 1/21 (2006.01) G01N 33/53 (2006.01)
Patent
CA 2288433
Methods and compositions for conferring tick immunity and preventing or reducing the transmission of tick-borne pathogens. I. scapularis polypeptides and fragments, fusion and multimeric proteins, DNA molecules encoding them, antibodies directed against the polypeptides, fusion proteins or multimeric proteins. Vaccines comprising I. scapularis polypeptides alone or in addition to other protective polypeptides. Methods comprising the polypeptides, antibodies and vaccines.
La présente invention concerne des compositions et procédés d'immunisation contre les tiques et de prévention ou de réduction de la pathogénicité des agents véhiculés par les tiques. L'invention concerne notamment des polypeptides et fragments de I. scapularis, certaines de leurs protéines de fusion et multimères, des molécules d'ADN les codant, des anticorps dirigés contre ces polypeptides, certaines de leurs protéines de fusion ou de leurs protéines multimères. L'invention concerne en outre des vaccins comprenant des polypeptides de I. scapularis seuls ou an adjonction à d'autres polypeptides protecteurs. L'invention concerne enfin des procédés portant sur ces polypeptides, anticorps et vaccins.
Das Subrata
Fikrig Erol
Kantor Fred S.
Nazario Sylvette
Smart & Biggar
Yale University
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