Compositions and methods for controlled-release delivery and...

A - Human Necessities – 61 – K

Patent

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A61K 47/30 (2006.01) A61K 47/10 (2006.01)

Patent

CA 2389304

The present invention relates to compositions and methods for improved efficacy of pharmaceutical compounds and controlled-release drug delivery systems. Using the process of hydrophobic ion pairing, antimicrobials having improved antimicrobial activity and anticancer agents having improved cytotoxic activity, as well as other pharmaceuticals, are provided. The present invention also relates to the use of poloxamer gels to deliver hydrophobic ion-paired pharmaceuticals.

L'invention concerne des compositions ainsi que des procédés permettant d'améliorer l'efficacité de composés pharmaceutiques et de systèmes d'apport de médicaments à libération retard. Elle concerne encore l'utilisation du procédé d'appariement d'ions hydrophobes, l'utilisation d'antimicrobiens possédant une activité antimicrobienne améliorée et d'agents anticancéreux possédant une activité cytotoxique améliorée, de même que d'autres produits pharmaceutiques. L'invention concerne encore l'utilisation de gels de poloxamère servant à l'apport de produits pharmaceutiques à ions appariés hydrophobes.

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