Compositions and methods for counteracting effects of...

C - Chemistry – Metallurgy – 07 – K

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C07K 7/06 (2006.01) C07K 5/113 (2006.01) C07K 7/08 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2389429

Peptide compounds and methods for upregulating expression of a gene encoding an antioxidative enzyme, such as superoxide dismutase or catalase, to counteract harmful oxidative effects of reactive oxygen species and other free radicals are described. The peptide compounds may be used to treat or prevent diseases and conditions characterized by undesirable elevation of reactive oxygen species and other free radicals, to upregulate AP-1 gene expression, and to treat pain. The peptide compounds may be used as components of pharmaceuticals and dietary supplements.

Cette invention concerne des composés peptidiques et des méthodes permettant de réguler à la hausse l'expression d'un gène codant pour une enzyme antioxydante tel qu'une superoxyde dismutase ou catalase dans le but de contrer les effets oxydants nocifs d'espèces réagissant à l'oxygène et autres radicaux libres. Ces composés peptidiques peuvent s'utiliser pour le traitement et la prévention de maladies et de manifestations caractérisées par une élévation indésirables d'espèces réagissant à l'oxygène et autres radicaux libres par régulation à la hausse du gène AP-1, ainsi que pour le traitement de la douleur. Ces composés peptidiques peuvent entrer dans la composition de produits pharmaceutiques et de compléments diététiques.

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