C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/24 (2006.01) A61K 39/395 (2006.01) C07K 16/00 (2006.01)
Patent
CA 2697163
The present invention relates to a batch crystallization method for crystallizing anti-human TNFalpha (hTNFalpha) antibody and antibody fragments which allows the production of said antibody on an industrial scale; a method of controlling the size of antibody crystals, for example, crystals of anti-hTNFalpha antibody fragments, compositions containing said crystals as well as methods of use of said crystals and compositions.
La présente invention se rapporte à un procédé de cristallisation discontinu permettant de cristalliser l'anticorps et les fragments d'anticorps antihumain TNFalpha (hTNFalpha). Ce procédé permet la production dudit anticorps à l'échelle industrielle. L'invention concerne également un procédé de contrôle de la taille de cristaux d'anticorps, par exemple, de cristaux de fragments d'anticorps anti-hTNFalpha, les compositions contenant lesdits cristaux ainsi que les procédés d'utilisation des cristaux et des compositions.
Borhani David W.
Fraunhofer Wolfgang
Gottschalk Stefan
Winter Gerhard
Abbott Laboratories
Torys Llp
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