Compositions and methods for delivery of a molecule into a cell

Details Compositions and methods for delivery of a molecule into a cell Compositions and methods for delivery of a molecule into a cell

A - Human Necessities

61

K

A61K 48/00 (2006.01) A61K 31/7088 (2006.01) A61K 38/16 (2006.01) A61K 39/21 (2006.01) A61K 41/00 (2006.01) A61K 47/48 (2006.01) A61P 31/00 (2006.01) A61P 35/00 (2006.01) A61P 43/00 (2006.01) C07K 14/16 (2006.01) C12N 15/87 (2006.01)

Patent

CA 2407570

Provided is a composition comprising a Vpr polypeptide conjugated to a therapeutic molecule. Preferably, the Vpr comprises synthetic Vpr. The therapeutic molecule can comprise any molecule capable of being conjugated to Vpr or a fragment thereof, including a polypeptide, a polynucleotide, and/or a toxin. The invention additionally provides a method for delivering a molecule into a cell. The method comprises contacting the cell with a conjugate comprising a Vpr polypeptide conjugated to the molecule. The invention further provides a method for modulating the expression of a transgene in a cell, a method for killing a target cell population in a subject, a method for increasing the sensitivity of cells to radiation therapy, and a method for inhibiting cell proliferation.

L'invention concerne une composition renfermant un polypeptide Vpr conjugué à une molécule thérapeutique. De préférence, ledit polypeptide Vpr est un Vpr de synthèse. La molécule thérapeutique peut être n'importe quelle molécule capable de se conjuguer au Vpr ou à un fragment de celui-ci, notamment un polypeptide, un polynucléotide et/ou une toxine. L'invention concerne également une méthode permettant d'introduire une molécule dans une cellule, laquelle méthode consiste à mettre la cellule au contact d'un conjugué constitué d'un polypeptide Vpr conjugué à la molécule. L'invention concerne, en outre, un procédé de modulation de l'expression d'un transgène à l'intérieur d'une cellule, un procédé permettant de tuer une population de cellules cible chez un sujet, un procédé permettant d'accroître la sensibilité des cellules à la radiothérapie et un procédé d'inhibition de la prolifération cellulaire.

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