A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/02 (2006.01) A61K 39/112 (2006.01) A61K 48/00 (2006.01) C07H 21/04 (2006.01) C12N 1/00 (2006.01) C12N 1/20 (2006.01) C12N 15/00 (2006.01) C12P 21/04 (2006.01) C12P 21/06 (2006.01) G01N 33/53 (2006.01)
Patent
CA 2381755
The present application generally discloses delivery of an agent which can be therapeutic or prophylactic and, more particularly, the preparation and use of attenuated bacteria, such as Salmonella, containing a bacteriophage in which the genome of the bacteriophage has been modified to encode for a gene product of interest, e.g., an antigen or an anti-tumor protein. The bacteria functions as a vector for delivering the bacteriophage encoded gene product of interest to an appropriate site of action, e.g., the site of a solid tumor.
L'invention concerne, d'une manière générale, la délivrance d'un agent thérapeutique ou prophylactique, et plus particulièrement la préparation et l'utilisation d'une bactérie atténuée, du type salmonelle , contenant un bactériophage dont on a modifié le génome pour coder un produit génique visé, du type antigène ou protéine antitumorale. La bactérie tient lieu de vecteur, pour la délivrance du produit génique visé - qui est codé par le bactériophage - sur un site d'action approprié, du type site de tumeur solide.
Bermudes David G.
Clairmont Caroline A.
King Ivan C.
Osler Hoskin & Harcourt Llp
Vion Pharmaceuticals Inc.
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