A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/21 (2006.01) A61K 31/70 (2006.01) A61K 39/00 (2006.01) A61K 47/22 (2006.01) A61K 48/00 (2006.01) C07K 14/16 (2006.01) C12N 15/67 (2006.01) C12N 15/87 (2006.01)
Patent
CA 2153593
Methods of introducing genetic material into cells of an individual and compositions and kits for practicing the same are disclosed. The methods comprise the steps of contacting cells of an individual with a polynucleotide function enhancer and administering to the cells, a nucleic acid molecule that is free of retroviral particles. The nucleic acid molecule comprises a nucleotide sequence that encodes a protein that comprises at least one epitope that is identical or substantially similar to an epitope of a pathogen antigen or an antigen associated with a hyperproliferative or autoimmune disease, a protein otherwise missing from the individual due to a missing, non-functional or partially functioning gene, or a protein that produces a therapeutic effect on an individual. Methods of prophylactically and therapeutically immunizing an individual against HIV are disclosed. Pharmaceutical compositions and kits for practicing methods of the present invention are disclosed.
Coney Leslie R.
Merva Michael J.
Wang Bin
Weiner David B.
Williams William V.
Coney Leslie R.
Merva Michael J.
Smart & Biggar
Wang Bin
Weiner David B.
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