A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/337 (2006.01) A61K 9/08 (2006.01) A61K 9/10 (2006.01) A61K 9/14 (2006.01) A61K 9/51 (2006.01) A61K 47/44 (2006.01) A61P 31/00 (2006.01) A61K 9/16 (2006.01)
Patent
CA 2461556
The present embodiment of the invention is generally directed to compositions comprising suspensions of poorly water soluble compounds recrystallized in nanoparticulate sizes ranging from 0.1 to 5 µm. In addition, the embodiment of the invention is directed to methods for preparation and administration of these compositions to a patient for prevention and treatment of disease states. In particular, the embodiment of the invention is directed to compositions comprising suspensions of poorly water-soluble compounds, such as antimitotics and antibiotics, in nanoparticulates and methods of prevention and treatment of chronic disease states, such as cancer, by intraperitoneal and intravenous administration of such compositions.
Le présent mode de réalisation de l'invention concerne, de manière générale, des compositions comprenant des suspensions de composés faiblement hydrosolubles recristallisés à des dimensions nanoparticulaires comprises entre 0,1 et 5 µm. De plus, ledit mode de réalisation de l'invention concerne des méthodes de préparation et d'administration desdites compositions à un patient destinées à la prévention et au traitement d'états pathologiques. En particulier, ledit mode de réalisation de l'invention concerne des compositions comprenant des suspensions de composés faiblement hydrosolubles, tels que des antimitotiques et des antibiotiques, à dimensions nanoparticulaires et des méthodes de prévention et de traitement d'états pathologiques chroniques, tels que le cancer, par administration intrapéritonéale et intraveineuse desdites compositions.
Jonas Jeffrey M.
Rajewski Roger A.
Subramaniam Bala
Terranova Katherine Fern
Crititech Inc.
Smart & Biggar
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