Compositions and methods for delivery of proteins and...

Details Compositions and methods for delivery of proteins and... Compositions and methods for delivery of proteins and...

C - Chemistry, Metallurgy

07

K

C07K 17/02 (2006.01) A01N 37/18 (2006.01) A61K 9/00 (2006.01) A61K 9/16 (2006.01)

Patent

CA 2452382

Hydrophobic ion pairing (HIP) is applied to solubilize proteins and/or adjuvants in an organic medium. A polymer is cosolubilized in the medium and microspheres encapsulating the protein and/or adjuvant can be produced by a single emulsion method. Microspheres prepared by this method exhibit low initial burst of the protein and gradual release over time, and elicit a strong and comprehensive immune response. Compositions comprising a protein and an adjuvant co-encapsulated in microspheres are provided.

Selon l'invention, un appariement ionique hydrophobe (HIP) est appliqué pour solubiliser des protéines et/ou des adjuvants dans un milieu organique. Un polymère est co-solubilisé dans le milieu et des microsphères encapsulant la protéine et/ou l'adjuvant peuvent être produites par un unique procédé d'émulsion. Les microsphères produites grâce à ce procédé fournissent une faible salve initiale de protéine puis une libération progressive au cours du temps, et déclenchent une réaction immunitaire forte et complète. L'invention a également pour objet des compositions une protéine et un adjuvant co-encapsulés dans des microsphères.

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