Compositions and methods for dendritic cell-based immunotherapy

Details Compositions and methods for dendritic cell-based immunotherapy Compositions and methods for dendritic cell-based immunotherapy

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) C12N 5/0784 (2010.01) A61K 35/12 (2006.01) A61K 39/00 (2006.01) A61P 35/00 (2006.01) C07K 14/535 (2006.01) C07K 14/71 (2006.01) C07K 19/00 (2006.01)

Patent

CA 2403964

Disclosed are immunostimulatory fusion proteins and methods for generating protective DC-induced, T cell-mediated immune responses in vitro and in vivo. The immunostimulatory fusion proteins comprise a polypeptide antigen component and an immunostimulatory component derived from the intracellular domain of the HER-2 protein. Also disclosed are immunostimulatory compositions comprising dendritic cells pulsed with such an immunostimulatory fusion protein and methods for immunotherapy using the compositions.

L'invention concerne des protéines de fusion immunostimulatrices et des méthodes permettant de générer in vitro et in vivo des réactions immunitaires de protection déclenchées par des lymphocytes et induites par des cellules dendritiques. Ces protéines de fusion immunostimulatrices comprennent un composant antigénique polypeptidique et un composant immunostimulateur dérivés du domaine intracellulaire de la protéine HER-2. L'invention concerne également des compositions immunostimulatrices comprenant des cellules dendritiques impulsées par une protéine de fusion immunostimulatrice selon l'invention ainsi que des méthodes d'immunothérapie faisant appel à ces compositions.

Affiliated with

Also associated with

Rating

Compositions and methods for dendritic cell-based immunotherapy does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Compositions and methods for dendritic cell-based immunotherapy, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Compositions and methods for dendritic cell-based immunotherapy will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1886821