Compositions and methods for dermal delivery of drugs

Details Compositions and methods for dermal delivery of drugs Compositions and methods for dermal delivery of drugs

A - Human Necessities

61

K

A61K 9/00 (2006.01) A61K 31/00 (2006.01) A61K 47/30 (2006.01)

Patent

CA 2633464

The present invention is drawn to adhesive formulations, methods of drug delivery, and solidified layers for dermal delivery of a drug. The formulation can include a drug, a solvent vehicle, and at least one solidifying agent. The solvent vehicle can have a volatile solvent system including at least one volatile solvent, and a non-volatile solvent system including at least one non- volatile solvent. The formulation can be formulated to contain at least two volatile solvents, at least two non-volatile solvents, or at least two solidifying agents. The formulation can have a viscosity suitable for application to a skin surface prior to evaporation of the volatile solvents system. When applied to the skin, the formulation can form a solidified layer after at least a portion of the volatile solvent system is evaporated.

La présente invention concerne des formulations adhésives, des procédés d'administration de médicament, et des couches solidifiées pour administration dermique d'un médicament. La formulation peut comprendre un médicament, un véhicule solvant, et au moins un agent solidifiant. Le véhicule solvant peut présenter un système de solvants volatil comprenant au moins un solvant volatil, et un système de solvants non volatil comprenant au moins un solvant non volatil. La formulation peut être formulée pour contenir au moins deux solvants volatils, au moins deux solvants non volatils, ou au moins deux agents solidifiants. La formulation peut présenter une viscosité convenant à une application sur la surface de la peau avant évaporation du système de solvants volatil. Une fois appliquée à la peau, la formulation peut constituer une couche solidifiée après évaporation d'au moins une partie du système de solvants volatil.

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