Compositions and methods for dermally treating pain

Details Compositions and methods for dermally treating pain Compositions and methods for dermally treating pain

A - Human Necessities

61

K

A61K 9/12 (2006.01)

Patent

CA 2633515

The present invention is drawn to solidifying formulations for dermal delivery of a drug for treating pain, such as musculoskeletal pain, inflammation, joint pain, or neuropathic pain. The formulation can include a drug selected from certain drug classes, a solvent vehicle, and a solidifying agent. The solvent vehicle can include a volatile solvent system comprising at least one volatile solvent, and a non-volatile solvent system comprising at least one non- volatile solvent, wherein the evaporation of at least some of the volatile solvent converts the formulation on the skin into a solidified layer and the non-volatile solvent system is capable of facilitating the topical delivery of the drug(s) at therapeutically effective rates over a sustained period of time.

La présente invention concerne la solidification de formulations pour l'administration dermique d'un médicament pour traiter la douleur, telle qu'une douleur musculosquélettique, une inflammation, une douleur d'articulation, ou une douleur neuropathique. La formulation peut comporter un médicament sélectionné parmi certaines classes de médicaments, un véhicule à base de solvant, et un agent de solidification. Le véhicule à base de solvant peut comporter un système solvant volatile comprenant au moins un solvant volatile, et un système solvant non volatile comprenant au moins un solvant non volatile, l'évaporation d'au moins une partie du solvant volatile convertit la formulation sur la peau en une couche solidifiée et le système solvant non volatile est capable de faciliter l'administration topique du/des médicament(s) à des taux thérapeutiques efficaces sur une période de temps prolongée.

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