Compositions and methods for detecting and treating diseases...

C - Chemistry – Metallurgy – 07 – K

Patent

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C07K 16/28 (2006.01) C12N 5/00 (2006.01) C12Q 1/04 (2006.01) G01N 33/53 (2006.01) G01N 33/566 (2006.01) G01N 33/567 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2468407

Compositions and Methods for Detecting and Treating Diseases and Conditions Related to Chemokine ReceptorsABSTRACT OF THE DISCLOSUREThe present invention provides methods for identifying an agent that specifically binds and/or modulates one topology of chemokine receptor but not a second topology of the receptor. Such agents are useful as therapeutics for diseases or conditions associated with a particular chemokine receptor topology. Moreover, the agents are useful for detecting a particular topology of a chemokine receptor, thereby diagnosing disease or predisposition for a disease. In addition, the agents are useful for identifying and isolating cells that express a particular topology of a chemokine receptor.

L'invention concerne des méthodes d'identification d'un agent qui se lie de manière spécifique à une topologie de récepteur de chimiokine et/ou qui module celle-ci, sans se lier à une seconde topologie dudit récepteur ni moduler cette dernière. Ces agents sont utiles en tant qu'agents thérapeutiques pour des maladies et des états associés à une topologie de récepteur de chimiokine particulière. Lesdits agents servent également à détecter une topologie particulière d'un récepteur de chimiokine, ce qui permet de diagnostiquer une maladie ou une prédisposition à une maladie. En outre, les agents servent à identifier et à isoler des cellules qui expriment une topologie particulière d'un récepteur de chimiokine.

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