C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01)
Patent
CA 2609636
The invention is based upon the discovery that small nucleic acids from non- viral pathogens are able to cross the kidney and are present in urine of a subject when the subject is infected with the non- viral pathogen. These transrenal DNAs are especially prevalent at smaller sizes under about 300 bp. Thus the invention provides compositions and methods for the diagnosis of infection of a subject with non- viral pathogens through the detection of transrenal nucleic acids from those pathogens in the urine of the subject.
L'invention est basée sur la découverte d'acides nucléiques de petite taille d'agents pathogènes non viraux, pouvant passer dans le rein et présents dans l'urine d'un sujet lorsque celui-ci est infecté par un agent pathogène non viral. Ces ADNs transrénaux sont particulièrement prédominants à des dimensions inférieures à environ 300 bp. L'invention concerne donc des compositions et des méthodes de diagnostic de l'infection d'un sujet par des agents pathogènes non viraux, par détection des acides nucléiques transrénaux desdits agents pathogènes dans l'urine du sujet.
Cannas Angela
Milkman Hooves
Tomei Louis David
Umansky Samuil R.
Istituto Nazionale Per Le Malattie Infettive Irccs Lazzaro Spall
Ridout & Maybee Llp
Trovagene Inc.
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