C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 9/22 (2006.01) C07K 14/00 (2006.01) C12N 9/00 (2006.01) C12Q 1/68 (2006.01)
Patent
CA 2169837
Briefly stated, the present invention provides novel compositions and methods for detecting target nucleic acid sequences utilizing adjacent sequence-enzyme molecules. Within one aspect of the present invention, oligonucleotide-enzyme fusion molecules are provided, comprising an enzyme capable of cleaving scissile linkages and an oligonuleotide having the structure (NA1)x-S2-(NA2)y wherein NA1 and NA2 are nucleic acid sequences, is a scissile nucleic acid linkage, x, y, and z are integers from 1 to 1,000 and n is an integer from 1 to 10.
En bref, cette invention se rapporte à de nouvelles compositions et à de nouveaux procédés pour détecter des séquences d'acides nucléiques cibles en utilisant des molécules enzymes-séquences adjacentes. Dans l'un de ses aspects, cette invention concerne des molécules de fusion enzymes-oligonucléotides, qui comprennent une enzyme capable d'effectuer le clivage de liaisons scissiles et un oligonucléotide ayant la structure (NA1)x-S2-(NA2)y où NA1 et NA2 sont des séquences d'acides nucléiques, S est une liaison d'acides nucléiques scissile, x, y et z sont des nombres entiers compris entre 1 et 1 000 et n est un nombre entier compris entre 1 et 10.
Bekkaoui Faouzi
Crosby William L.
Duck Peter D.
Tullis Richard H.
Gowling Lafleur Henderson Llp
Id Biomedical Corporation
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