C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01)
Patent
CA 2480276
The present invention relates to methods for treatment and diagnosis of disorders associated with abnormally proliferating cells. In one aspect the invention relates to methods, which are especially useful for the detection of tumors and their precursory stages based on the detection of overexpression of human transketolase like-1 gene in biological samples. In another aspect the invention relates to methods for treatment of disorders associated with the overexpression of human transketolase like-1 gene. Methods for treatment may include gene therapeutic approaches as well as methods for inhibiting or reducing the activity of transketolase like-1 polypeptides.
La présente invention concerne des méthodes de traitement et de diagnostic de troubles associés à des cellules proliférant de façon anormale. Dans un certain aspect, cette invention concerne des méthodes particulièrement utiles dans la détection de tumeurs et de leurs stades précurseurs, lesquelles méthodes sont basées sur la détection de la surexpression du gène de la transcétolase de type 1 humaine dans des prélèvements biologiques. Dans un autre aspect, cette invention concerne des méthodes de traitement de troubles associés à la surexpression du gène de la transcétolase de type 1 humaine, parmi lesquelles figurent des approches thérapeutiques génétiques ainsi que des méthodes d'inhibition ou de réduction de l'activité de polypeptides de la transcétolase de type 1.
Borden Ladner Gervais Llp
Coy Johannes
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