G - Physics – 01 – N
Patent
G - Physics
01
N
G01N 33/554 (2006.01) C07K 16/08 (2006.01) C07K 16/34 (2006.01) C12Q 1/04 (2006.01) C12Q 1/24 (2006.01) G01N 33/53 (2006.01) G01N 33/541 (2006.01) G01N 33/555 (2006.01) G01N 33/567 (2006.01) G01N 33/80 (2006.01)
Patent
CA 2268339
The invention relates to methods of agglutinating or capturing cells comprising providing a mixture comprising a population of cells and a population of bacteriophage expressing a first antibody on the surface of the bacteriophage, the first antibody being specific for an antigen-bearing moiety expressed by at least a portion of the cells in the cell population, wherein the first antibody binds to the portion of the cells causing the bacteriophage to also bind to the portion of the cells, adding to the mixture a second antibody specific for the bacteriophage, wherein binding of the second antibody to bacteriophage bound to the portion of the cells causes the portion of the cells to agglutinate or be captured.
L'invention concerne des méthodes permettant d'agglutiner ou de capturer des cellules. Selon ces méthodes, on forme un mélange constitué d'une population de cellules et d'une population de bactériophages exprimant un premier anticorps à la surface dudit bactériophage, le premier anticorps étant spécifique d'un fragment porteur d'antigène exprimé par au moins une partie des cellules de la population cellulaire. Le premier anticorps se fixe sur ladite partie des cellules, ce qui entraîne la fixation du bactériophage sur ladite partie. Puis on ajoute au mélange un second anticorps spécifique du bactériophage, la fixation dudit second anticorps sur le bactériophage fixé sur la partie des cellules entraînant l'agglutination ou la capture de ladite partie.
Gowling Lafleur Henderson Llp
The Trustees Of The University Of Pennsylvania
LandOfFree
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