C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01)
Patent
CA 2724552
The present invention provides compositions and methods for the detection of nucleic acid sequences associated with chromosomal aberrations. The invention may, for example, eliminate the use of, or reduce the dependence on formamide in hybridization. Compositions for use in the invention include an aqueous composition comprising at least one nucleic acid sequence and at least one polar aprotic solvent in an amount effective to denature double-stranded nucleotide sequences.
La présente invention concerne des compositions et des procédés pour la détection de séquences dacides nucléiques associées à des aberrations chromosomiques. Linvention peut, par exemple, éliminer lutilisation de formamide en hybridation ou en réduire la dépendance. Des compositions selon linvention comportent une composition aqueuse comprenant au moins une séquence dacides nucléiques et au moins un solvant polaire aprotique en une quantité suffisante pour dénaturer des séquences nucléotidiques double-brin.
Matthiesen Steen Hauge
Petersen Kenneth H.
Poulsen Tim Svenstrup
Dako Denmark A/s
Fetherstonhaugh & Co.
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