Compositions and methods for determining interactions of...

Details Compositions and methods for determining interactions of... Compositions and methods for determining interactions of...

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) C07K 14/435 (2006.01) C07K 14/47 (2006.01) C12N 1/21 (2006.01) C12N 5/10 (2006.01) C12N 9/90 (2006.01) C12N 15/61 (2006.01) C12N 15/62 (2006.01) G01N 33/50 (2006.01) G01N 33/533 (2006.01) G01N 33/542 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2389754

Compositions and methods are provided for identifying agents that alter mitochondrial membrane permeability transition. The screening methods generally detect agents that alter the interaction between the mitochondrial adenine nucleotide translocator and cyclophilin D. Such agents may be used, for example, in the treatment of a variety of conditions associated with altered mitochondrial function.

L'invention concerne des compositions et des techniques permettant d'identifier des agents modifiant la transition de la perméabilité mitochondriale de la membrane. Ces techniques de criblage permettent généralement de détecter des agents modifiant l'interaction entre le translocateur mitochondrial de nucléotide adénine et la cyclophiline D. Ces agents peuvent s'utiliser notamment dans le traitement de plusieurs états associés à une altération de la fonction mitochondriale.

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