C - Chemistry – Metallurgy – 07 – H
Patent
C - Chemistry, Metallurgy
07
H
C07H 21/00 (2006.01) C12Q 1/37 (2006.01) C12Q 1/68 (2006.01) C12Q 1/70 (2006.01)
Patent
CA 2491395
The present invention provides an approach for developing an algorithm for determining the effectiveness of anti-viral drugs based on a comprehensive analysis of paired phenotypic and genotypic data guided by phenotypic clinical cut-offs. In one aspect, the algorithm allows one to provide a patient with effective treatment. It helps predict whether an infected individual will respond to treatment with an anti-viral compound, thereby allowing an effective treatment regimen to be designed without subjecting the patient to unnecessary side effects. Also, by avoiding the administration of ineffective drugs, considerable time and money is saved.
La présente invention concerne une approche d'élaboration d'un algorithme permettant de déterminer l'efficacité de médicaments antiviraux fondé sur une analyse exhaustive de données génotypiques et phénotypiques appariées guidée par des échantillons cliniques phénotypiques. Dans un aspect, cet algorithme permet de fournir un traitement efficace à un patient. Il aide à prévoir si une personne infectée répondra à un traitement par un composé antiviral, ce qui permet de désigner un schéma posologique de traitement efficace sans soumettre le patient à des effets secondaires indésirables. Par ailleurs, on peut économiser un temps considérable et beaucoup d'argent en évitant d'administrer des médicaments inefficaces.
Chappey Colombe
Parkin Neil T.
Petropoulos Christos J.
Monogram Biosciences Inc.
Osler Hoskin & Harcourt Llp
Virologic Inc.
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