Compositions and methods for determining the susceptibility...

C - Chemistry – Metallurgy – 12 – Q

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C12Q 1/70 (2006.01) A61K 39/21 (2006.01) C07H 21/04 (2006.01) C12Q 1/37 (2006.01) C12Q 1/68 (2006.01) G01N 33/569 (2006.01)

Patent

CA 2491388

The present invention provides an approach for developing an algorithm for determining the effectiveness of anti-viral drugs based on a comprehensive analysis of paired phenotypic and genotypic data guided by phenotypic clinical cut-offs. In one aspect, the algorithm allows one to provide a patient with effective treatment. It helps predict whether an infected individual will respond to treatment with an anti-viral compound, thereby allowing an effective treatment regimen to be designed without subjecting the patient to unnecessary side effects. Also, by avoiding the administration of ineffective drugs, considerable time and money is saved.

La présente invention concerne une approche permettant d'élaborer un algorithme servant à mesurer l'efficacité de médicaments antiviraux sur la base d'une analyse compréhensive par paires de données phénotypiques et génotypiques fondée sur des limites cliniques phénotypiques. Dans un aspect de l'invention, l'algorithme permet de fournir un traitement efficace à un patient. L'algorithme permet de prévoir si un individu infecté va être sensible à un traitement avec un composé antiviral et, ainsi, d'élaborer un régime thérapeutique adapté, sans soumettre le patient à des effets secondaires inutiles. Par ailleurs, le fait de ne pas administrer de médicaments inefficaces permet un gain de temps et d'argent considérable.

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