Compositions and methods for diagnosing and treating asthma...

C - Chemistry – Metallurgy – 12 – N

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C12N 15/11 (2006.01) A61K 31/198 (2006.01) A61K 31/7088 (2006.01) A61K 49/00 (2006.01) A61P 11/06 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2517684

The present invention provides compositions and methods useful for detecting or treating asthma or other allergic or inflammatory diseases. In one aspect, the methods of the present invention include inhibiting the activity or expression of a component of an arginine metabolic pathway in tissues affected by asthma or other allergic or inflammatory diseases. In many embodiments, the component being inhibited is a cationic amino acid transporter, an arginase, or a component downstream of the arg nase. In many other embodiments, the activity or expression of the component is i bited by an agent that binds to the component. In still many other embodiments, the activity or expression of the component is inhibited by an agent that binds a polynucleotide encoding the component.

La présente invention a trait à des compositions et des procédés utiles pour la détection ou le traitement de l'asthme ou d'autres maladies allergiques ou inflammatoires. Un aspect de la présente invention comprend l'inhibition de l'activité ou de l'expression d'un composant d'une voie métabolique d'arginine dans des tissus affectés par l'asthme ou d'autres maladies allergiques ou inflammatoires. Dans plusieurs modes de réalisation, le composant inhibé est un transporteur d'acide aminé cationique, une arginase, ou un composant en aval de l'arginase. Dans plusieurs autres modes de réalisation, l'activité ou l'expression du composant est inhibée par un agent qui se lie au composants. Dans plusieurs autres modes de réalisation encore, l'activité ou l'expression du composant est inhibée par un agent qui se lie à un polynucléotide codant pour le composant.

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