C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/30 (2006.01) A61K 31/337 (2006.01) A61K 31/4745 (2006.01) A61K 31/555 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) A61P 35/00 (2006.01) C07K 16/28 (2006.01) G01N 33/574 (2006.01)
Patent
CA 2655362
The present invention relates to compositions and methods for characterizing, diagnosing, and treating cancer. In particular the invention provides the means and methods for the diagnosis, characterization, prognosis and treatment of cancer and specifically targeting cancer stem cells. The present invention provides an antibody that specifically binds to a non-ligand binding region of the extracellular domain of a human NOTCH receptor and inhibits growth of tumor cells. The present invention further provides a method of treating cancer, the method comprising administering a therapeutically effective amount of an antibody that specifically binds to a non-ligand binding region of the extracellular domain of a human NOTCH receptor protein and inhibits growth of tumor cells.
La présente invention concerne des compositions et des procédés destinés à la caractérisation, au diagnostic et au traitement du cancer. L'invention concerne en particulier les moyens et les procédés permettant de diagnostiquer, de caractériser, de pronostiquer et de traiter le cancer et spécifiquement de cibler des cellules souches cancéreuses. La présente invention concerne un anticorps qui se lie spécifiquement à une région de liaison d'un non ligand du domaine extracellulaire d'un récepteur NOTCH humain et inhibe la croissance de cellules tumorales. La présente invention concerne en outre un procédé de traitement du cancer, le procédé consistant à administrer une quantité thérapeutiquement efficace d'un anticorps qui se lie spécifiquement à une région de liaison d'un non ligand du domaine extracellulaire de la protéine réceptrice NOTCH et inhibe la croissance de cellules tumorales.
Gurney Austin
Hoey Timothy
Lewicki John
Satyal Sanjeev
Yen Wan-Ching
Mbm Intellectual Property Law Llp
Oncomed Pharmaceuticals Inc.
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