C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/28 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) A61P 35/00 (2006.01) C07K 16/30 (2006.01) C07K 16/46 (2006.01) C12N 5/16 (2006.01) C12N 15/13 (2006.01) C12N 15/63 (2006.01)
Patent
CA 2676008
Isolated antibodies that specifically binds to an extracellular conserved ligand binding region of a human Notch receptor and inhibits growth of a tumor are described. Also described are methods of treating cancer, the method comprising administering an anti-Notch antibody in an amount effective to inhibit tumor growth.
La présente invention concerne des anticorps isolés qui se lient spécifiquement à un domaine de liaison d'un ligand extracellulaire et conservé appartenant à un récepteur Notch humain, et inhibent le développement d'une tumeur. L'invention porte également sur des procédés permettant de traiter un cancer, le procédé consistant à administrer un anticorps anti-Notch dans une quantité efficace pour inhiber la croissance tumorale.
Fitch-Bruhns Maureen
Gurney Austin
Sato Aaron
Mbm Intellectual Property Law Llp
Oncomed Pharmaceuticals Inc.
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