C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/30 (2006.01) A61K 39/395 (2006.01) A61P 35/00 (2006.01) C07K 16/00 (2006.01) C07K 16/28 (2006.01) C07K 16/46 (2006.01) C12N 5/16 (2006.01) C12N 15/13 (2006.01) C12P 21/08 (2006.01) C07K 14/705 (2006.01)
Patent
CA 2664738
An isolated antibody that specifically binds to an extracellular domain of human DLL4 and affects growth of a tumor comprising cancer stem cells is described. Also described is a method of treating cancer comprising administering a therapeutically effective amount of an anti-DLL4 antibody.
L'invention concerne un anticorps isolé qui se fixe de manière spécifique à un domaine extracellulaire de DLL4 humain et affecte la croissance d'une tumeur comprenant des cellules souches cancéreuses. L'invention concerne également un procédé pour traiter le cancer comprenant l'administration d'une quantité efficace de manière thérapeutique d'un anticorps anti-DLL4.
Axelrod Fumiko
Gurney Austin
Hoey Timothy
Satyal Sanjeev
Mbm Intellectual Property Law Llp
Oncomed Pharmaceuticals Inc.
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