Compositions and methods for diagnosing colon disorders

C - Chemistry – Metallurgy – 12 – Q

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C12Q 1/68 (2006.01)

Patent

CA 2587670

The present invention relates to methods and compositions for diagnosing, monitoring, prognosticating, analyzing, etc., polymicrobial diseases. The present invention also relates to the microbial community present in the digestive tract and lumen in normal subjects, and subjects with digestive tract diseases, especially diseases of the colon, such as inflammatory bowel disease, including ulcerative colitis, Crohn~s syndrome, and pouchitis. The present invention especially relates to compositions and methods for diagnosing and prognosticating the mentioned diseases and conditions, e.g., to determine the presence of the disease in a subject, to determine a therapeutic regimen, to determine a therapeutic regimen, to dertermine the onset of active disease, to determine the predisposition to the disease, etc.

La présente invention concerne des méthodes et des compositions pour le diagnostic, la surveillance, le pronostic, l'analyse, etc., de maladies polymicrobiennes. La présente invention concerne également la communauté microbienne présente dans le tube digestif et la lumière digestive chez des sujets normaux, ainsi que chez des sujets présentant des maladies du tube digestif, en particulier des maladies du côlon, telles que les maladies intestinales inflammatoires, notamment la colite ulcéreuse, le syndrome de Crohn et la pochite. La présente invention concerne en particulier des compositions et des méthodes pour le diagnostic et le pronostic des maladies et pathologies susmentionnées, par exemple, afin de déterminer la présence de la maladie chez un sujet, afin de déterminer un régime thérapeutique, afin de déterminer l'apparition de maladies actives, afin de déterminer la prédisposition à la maladie, etc.

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