Compositions and methods for diagnosing or treating psoriasis

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/12 (2006.01) C07H 21/00 (2006.01) C07K 14/47 (2006.01) C07K 16/00 (2006.01) C12N 15/63 (2006.01) G01N 33/53 (2006.01)

Patent

CA 2428319

In one aspect, the present invention provides isolated nucleic acid molecules that encode a CAN-1 polypeptide, or an STG polypeptide. In another aspect, the present invention also provides isolated STG polypeptides, isolated CAN-1 polypeptides, and isolated SEEK-1 polypeptides. In another aspect, the present invention provides isolated antibodies that bind specifically to a CAN-1, SEEK- 1 or STG polypeptide. In another aspect, the present invention provides methods of diagnosing or predicting the susceptibility to psoriasis of an individual. In another aspect, the present invention provides methods for ameliorating the symptoms and/or progression os psoriasis.

Dans un aspect, la présente invention concerne des molécules d'acide nucléique isolés codant un polypeptide CAN-1 ou un polypeptide STG. Dans un autre aspect, l'invention concerne des polypeptides STG isolés, des polypeptides CAN-1 isolés, et des polypeptides SEEK-1 isolés. Dans un autre aspect, l'invention concerne des anticorps isolés qui se lient spécifiquement à un polypeptide CAN-1, SEEK-1 ou STG. Dans un autre aspect, l'invention concerne des méthodes permettant de diagnostiquer ou de prédire la sensibilité d'un individu au psoriasis. Dans un autre aspect, l'invention concerne des méthodes qui peuvent améliorer les symptômes et/ou l'évolution du psoriasis.

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