C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 31/70 (2006.01) A61K 48/00 (2006.01) C07K 14/435 (2006.01) C07K 14/47 (2006.01) G01N 33/53 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2283932
Methods and compositions are described that are useful for diagnosing and/or treating disease arising from unwanted cell growth, preferably cancer, involving diagnosing cells for stabilized beta-catenin, or treating cells with compounds that disrupt or alter the formation of a complex consisting of beta- catenin/transcription factor, where the transcription factor is a member of the Lef/Tcf family.
La présente invention concerne des procédés et des compositions utilisées pour diagnostiquer et/ou traiter une maladie provenant d'une croissance indésirable des cellules, de préférence le cancer. Ledit procédé consiste à opérer un diagnostic sur des cellules à la recherche de bêta-caténine stabilisée ou à traiter des cellules avec des composés qui interrompent ou modifient la formation d'un complexe constitué d'un facteur de transcription et de bêta-caténine, le facteur de transcription étant un élément de la famille Lef/Tcf.
Polakis Paul
Rubinfeld Bonnee
Fetherstonhaugh & Co.
Onyx Pharmaceuticals Inc.
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