Compositions and methods for diagnosis and therapy of...

C - Chemistry – Metallurgy – 12 – N

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C12N 15/12 (2006.01) A61K 38/17 (2006.01) A61K 48/00 (2006.01) A61P 35/00 (2006.01) C07K 14/47 (2006.01) A61K 38/00 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2401070

Disclosed are compositions and methods for the diagnosis and therapy of Wilms' tumor antigen-associated cancers, and in particular, mesotheliomas. In particular embodiments, the invention provides methods, compositions and kits for eliciting immune and T cell response to Wilms' tumor antigen polypeptide- derived antigenic fragments, and methods for the use of such compositions for diagnosis, detection, treatment, monitoring, and/or prevention of human malignant pleural mesothelioma.

L'invention concerne des compositions et des méthodes destinées au diagnostic et au traitement des cancers associés à l'antigène de la tumeur de Wilms, et en particulier des mésothéliomes. Dans des modes de réalisation particuliers, l'invention concerne de nouvelles méthodes efficaces, des compositions et des kits permettant d'éliciter une réponse immunitaire et une réponse des lymphocytes T aux fragments antigéniques dérivés des polypeptides de l'antigène de la tumeur de Wilms, ainsi que des méthodes d'utilisation de ces compositions dans le diagnostic, la détection, le traitement, le suivi et/ou la prévention du mésothéliome malin de la plèvre chez l'homme.

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