Compositions and methods for eliciting ctl immunity

Details Compositions and methods for eliciting ctl immunity Compositions and methods for eliciting ctl immunity

A - Human Necessities

61

K

A61K 39/00 (2006.01) A61K 39/29 (2006.01) A61K 39/295 (2006.01) A61K 39/39 (2006.01) C07K 14/02 (2006.01) C07K 14/025 (2006.01) C07K 14/11 (2006.01) C07K 14/16 (2006.01) C07K 14/18 (2006.01) C07K 14/33 (2006.01) C07K 14/705 (2006.01)

Patent

CA 2183416

Cytotoxic T lymphocyte responses are effectively induced to an antigen of interest, particularly viral, bacterial, parasitic and tumor antigens. Compositions, including pharmaceutical compositions, of CTL-inducing peptide and an adjuvant or a lipidated peptide which induces a helper T cell (HTL) response stimulate the antigen specific CTL response. Among the viral antigens to which the CTL responses are effectively induced in humans are those of hepatitis B. The CTL response may be optimized by a regimen of two or more booster administrations. Coktails of two or more CTL inducing peptides are employed to optimize epitope and/or MHC class 1 restricted coverage.

Les réponses des lymphocytes T cytotoxiques sont induites de manière efficace contre l'antigène étudié, et plus particulièrement les antigènes bactériens, parasitaires et tumoraux. Les compositions, y compris les compositions pharmaceutiques, à base de peptides induisant des lymphocytes T cytotoxiques et un adjuvant ou un peptide lipidé induisant une réponse des cellules T auxiliaires stimulent la réponse des lymphocytes T cytotoxiques spécifique à l'antigène. Les antigènes viraux contre lesquels les réponses des lymphocytes T cytotoxiques sont induites efficacement sont ceux de l'hépatite B. La réponse des lymphocytes T cytotoxiques peut être optimisée par un régime de deux administrations de rappel ou plus. Des cocktails de deux peptides induisant des lymphocytes T cytotoxiques ou plus sont utilisés pour optimiser l'épitope et/ou la couverture réduite de classe I du complexe majeur d'histocompatibilité.

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