C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/62 (2006.01) A61K 31/7052 (2006.01) A61K 38/18 (2006.01) A61K 39/385 (2006.01) A61K 48/00 (2006.01) C07K 14/52 (2006.01) C07K 19/00 (2006.01) C12N 15/12 (2006.01) C12N 15/85 (2006.01)
Patent
CA 2354255
The present invention relates to the use of nucleic acids which code for secretory fusion proteins to elicit immune responses. The secretory fusion protein comprises a signal sequence from a secretion competent protein, particularly a cytokine, which is linked in frame with the coding sequence of the antigen of interest which is normally intracellular. The nucleic acid encoding such a fusion protein is significantly more effective in its ability to elicit antibody production than the nucleic acid encoding the intracellular antigen. The present invention thus provides for a method of generating antibodies as well as a method of eliciting protective immune response using such nucleic acids. Also provided are pharmaceutical compositions comprising these nucleic acids.
Farrell Patrick J.
Gedamu Lashitew
Iatrou Kostas
Torys Llp
University Technologies International Inc.
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