Compositions and methods for eluting compounds from matrices

Details Compositions and methods for eluting compounds from matrices Compositions and methods for eluting compounds from matrices

A - Human Necessities

61

N

A61N 1/05 (2006.01) G01N 33/15 (2006.01)

Patent

CA 2747829

Embodiments of the invention provide to apparatuses and media used in drug elution studies and methods for making and using them. One embodiment of the invention is a drug elution method that can be used for in-vitro studies of a matrix impregnated with a compound such as a drug blended polymer matrix. Such methods and materials can be used for example to assess and control the manufacturing process variability of drug eluting implantable devices such as cardiac leads.

La présente invention porte, dans ses modes de réalisation, sur des appareils et des milieux utilisés dans des études d'élution de médicament et sur des procédés de fabrication et d'utilisation de ceux-ci. Un mode de réalisation de l'invention concerne un procédé d'élution de médicament pouvant être utilisé pour des études in vitro d'une matrice imprégnée par un composé telle qu'une matrice polymère mélangée à un médicament. De tels procédés et matériaux peuvent être utilisés par exemple pour évaluer et réguler la variabilité de processus de fabrication de dispositifs implantables éluant un médicament tels que des fils cardiaques.

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