Compositions and methods for enhanced mucosal delivery of y2...

A - Human Necessities – 61 – K

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A61K 38/17 (2006.01) A61P 3/04 (2006.01) A61K 9/00 (2006.01)

Patent

CA 2555826

Pharmaceutical compositions and methods are described comprising at lease one Y2 receptor-binding peptide, such as peptide YY (PYY), Neuropeptide Y (NPY) or Pancreatic Peptide (PP) and one or more mucosal delivery-enhancing agents for enhanced nasal mucosal delivery of the peptide YY, for treating a variety of diseases and conditions in mammalian subjects, including obesity.

La présente invention concerne des procédés et des compositions pharmaceutiques comprenant au moins un peptide se liant au récepteur Y2. Il s'agit notamment du Peptide YY (PYY), du Neuropeptide Y (NPY), ou du Peptide Pancréatique (PP). Il est accompagné d'au moins un agent renforçant l'apport aux muqueuses, de façon à renforcer l'apport aux muqueuses nasales du peptide YY. Cela permet de traiter diverses maladies et états affectant les mammifères, et notamment l'obésité.

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