A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/00 (2006.01) A61K 9/00 (2006.01) A61K 38/17 (2006.01)
Patent
CA 2510199
Pharmaceutical compositions and methods are described comprising at least one peptide YY compound and one or more intranasal delivery-enhancing agents for enhanced nasal mucosal delivery of the peptide YY, for treating a variety of diseases and conditions in mammalian subjects, including obesity. In one aspect, the intranasal delivery formulations and methods provide enhanced delivery of peptide YY to the blood plasma or central nervous system (CNS) tissue or fluid, for example, by yielding a peak concentration (Cmax) of the peptide YY in the blood plasma or CNS tissue or fluid of the subject that is 20% or greater compared to a peak concentration of the peptide YY in the blood plasma or CNS tissue or fluid of the subject following administration to the subject of a same concentration or dose of the peptide YY to the subject by subcutaneous injection.
L'invention concerne des compositions et des procédés correspondants. Les compositions renferment au moins un composé de peptide YY et un ou plusieurs agents d'administration intra-nasale assurant une administration améliorée aux muqueuses nasales du peptide YY, pour le traitement d'un éventail de maladies et d'affections chez les mammifères, y compris l'obésité. Selon un aspect, les formulations et les procédés considérés permettent d'améliorer l'administration de peptide YY au plasma sanguin ou bien à du tissu ou du fluide du système nerveux central, par exemple, en donnant une concentration maximum (C¿max?) de peptide YY dans le plasma, tissu ou fluide visé, qui dépasse de 20 % ou plus la concentration maximum en question après administration d'une concentration ou dose identique en injection sous-cutanée.
Brandt Gordon
Kleppe Mary S.
Macevilly Conor J.
Quay Steven C.
Borden Ladner Gervais Llp
Mdrna Inc.
Nastech Pharmaceutical Company Inc.
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