Compositions and methods for enhancing an adjuvant

Details Compositions and methods for enhancing an adjuvant Compositions and methods for enhancing an adjuvant

A - Human Necessities

61

K

A61K 39/39 (2006.01) A61K 47/48 (2006.01) A61P 37/04 (2006.01)

Patent

CA 2663851

Provided herein are compositions and methods for enhancing an adjuvant effect. The methods involve targeting an adjuvant to an antigen presenting cell (APC) using a compound that binds to a cell surface marker of an APC. Such methods are useful for stimulating an immune response in an animal, such as a human. Also provided are compositions that target an antigen and an adjuvant to an APC.

La présente invention concerne des compositions et des procédés permettant d'améliorer l'effet d'un adjuvant. Les procédés mettent en jeu le ciblage d'un adjuvant vers une cellule présentant l'antigène (Antigen Presenting Cell : APC) à l'aide d'un composé qui se lie à un marqueur sur la surface d'une APC. De tels procédés sont utilisables pour stimuler une réponse immunitaire chez un animal tel qu'un humain. L'invention concerne également des compositions qui ciblent un antigène et un adjuvant vers une APC.

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