Compositions and methods for enhancing antigen-specific...

Details Compositions and methods for enhancing antigen-specific... Compositions and methods for enhancing antigen-specific...

C - Chemistry, Metallurgy

12

N

C12N 15/63 (2006.01) A61P 35/00 (2006.01) C12N 15/12 (2006.01) C12N 15/85 (2006.01)

Patent

CA 2760310

Methods for treating or preventing recurrence of hyper proliferating diseases, e.g., cancer, are described. A method may comprise priming a mammal by administering to the mammal an effective amount of a nucleic acid composition encoding an antigen or a biologically active homo log thereof and boosting the mammal by administering to the mammal an effective amount of an oncolytic virus comprising a nucleic acid encoding the antigen or the biologically active homolog thereof.

L'invention porte sur des procédés de traitement ou de prévention de la récurrence de maladies hyper prolifératives, par exemple un cancer. Un procédé peut comprendre la mise en condition d'un mammifère par l'administration au mammifère d'une quantité efficace d'une composition d'acide nucléique codant pour un antigène ou un homologue biologiquement actif de celui-ci et l'exaltation de l'immunité du mammifère par l'administration au mammifère d'une quantité efficace d'un virus oncolytique comportant un acide nucléique codant pour l'antigène ou l'homologue biologiquement actif de celui-ci.

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