A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 49/18 (2006.01) A61K 9/127 (2006.01)
Patent
CA 2755998
Examples of compositions of liposomes and methods of making the same containing high concentrations of contrast-enhancing agents for computed tomography are provided. Example compositions of such liposomes, when administered to a subject, provide for increased contrast of extended duration, as measured by computed tomography, in the bloodstream and other tissues of the subject. Also provided are example methods for making the liposomes stable, that is, resistant to leakage of the contrast-enhancing agents, including the extrusion of the liposomes at high pressures and at high flow rates per total pore area of the extrusion filters.
La présente invention concerne des exemples de compositions de liposomes contenant de fortes concentrations d'agents améliorant les contrastes pour tomodensitométrie et des procédés permettant de les fabriquer. Des exemples de compositions de tels liposomes, lorsqu'elles sont administrées à un patient, apportent un contraste plus important pendant une durée plus longue, tels que mesurés par tomodensitométrie, dans la circulation sanguine et autres tissus du patient. L'invention concerne également des exemples de procédés permettant de rendre les liposomes stables, c'est-à-dire résistants aux fuites des agents améliorant le contraste, notamment l'extrusion des liposomes à pressions élevées et à débits élevés par région de pores totale des filtres d'extrusion.
Annapragada Ananth
Ghaghada Ketankumar B.
Lebovitz Russell M.
Board Of Regents Of The University Of Texas System
Marval Biosciences Inc.
Norton Rose Canada S.e.n.c.r.l.,s.r.l./llp
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