Compositions and methods for enhancing contrast in imaging

Details Compositions and methods for enhancing contrast in imaging Compositions and methods for enhancing contrast in imaging

A - Human Necessities

61

K

A61K 51/00 (2006.01) A61K 49/00 (2006.01)

Patent

CA 2563692

Example compositions of liposomes with hydrophilic polymers on their surface, and containing relatively high concentrations of contrast-enhancing agents for computed tomography are provided. Example pharmaceutical compositions of such liposomes, when administered to a subject, provide for increased contrast of extended duration, as measured by computed tomography, in the bloodstream and other tissues of the subject. Also provided are example methods for making the liposomes containing high concentrations of contrast~-enhancing agents, and example methods for using the compositions.

Aux fins de l'invention, on donne des compositions de liposomes comportant en surface des polymères hydrophiles et présentant des concentrations relativement élevées d'agents augmentant le contraste pour la tomographie par ordinateur, et lorsque ces compositions pharmaceutiques de liposomes sont administrées à un sujet, on améliore le contraste sur une durée étendue, selon les mesures effectuées en tomographie par ordinateur, dans le système circulatoire et autres tissus chez le sujet. L'invention concerne également des exemples de procédés qui permettent d'élaborer les liposomes à concentrations élevées d'agents augmentant le contraste, et des procédés relatifs à l'utilisation des compositions correspondantes.

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